9月30上午10点，麻省理工大学汪卫平博士受我组王启刚教授邀请来我同济大学化学科学与工程学院作了题为“Photoresponsive Nanoparticles for Drug Delivery ”的精彩学术报告。

       报告中，汪博士从分子设计到生物应用，系统地讲解了经过结构设计的纳米颗粒在光信号下能对肿瘤细胞进行药物可控释放，从而达到靶向治疗的目的，而且这种特殊设计的光响应控释方式能有效降低对正常细胞的副作用。

此外，由于汪博士之后将会在香港大学任教，组建自己的研究团队，所以汪博士对所有到场的学生发出了邀请，欢迎大家加入其研究团队。

   最后汪博士认真解答了各位老师和同学的提问，整个报告会在轻松而热烈的气氛中结束。

报告人简介：

汪卫平，Weiping Wang (Associate Professor, Dr Li Dak-Sum Research Centre, The University of Hong Kong)

Abstract: Light as an external stimulus allows spatiotemporal control over drug release and nanocarrier targeting (phototargeting), and can therefore enhance therapeutic efficacy while decreasing side effects. Here I will mainly present a general strategy to achieve phototargeting based on triplet–triplet annihilation upconversion (TTA-UC), which converts visible light to UV light. We designed photoresponsive polymeric nanoparticles with targeting ligands caged by photocleavable groups. TTA-UC followed by Förster resonance energy transfer (FRET) triggered the removal of the photocleavable groups and allowed binding of the nanoparticles to tumors with green light LED irradiation at low irradiance for short periods. The phototargeting can improve the specific targeting of the nanoparticles to tumors over liver and spleen, minimizing off-targeting effect. The long wavelength and low irradiance are attractive features for the potential clinical application of such systems.

Biography:

• Sep 2006–Aug 2011, Ph.D. from The Hong Kong University of Science and Technology.

• Jan 2012–Oct 2016, Research Fellow at Boston Children‘s Hospital, Harvard Medical School (HMS) & Postdoctoral Associate at Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT).

Weiping Wang has been selected as an Assistant Professor at the Dr Li Dak-Sum Research Centre, The University of Hong Kong - Karolinska Institutet Collaboration in Regenerative Medicine. His research interests include molecular engineering, biomaterials, drug delivery and genome editing.