2013年论文

1 Liao, Chuan-An

   Wu, Qing

   Wei, Qing-Cong

   Wang, Qi-Gang

Bioinorganic Nanocomposite Hydrogels Formed by HRP-GOx-Cascade-Catalyzed

   Polymerization and Exfoliation of the Layered Composites

CHEMISTRY-A EUROPEAN JOURNAL

VL 21

IS 36

BP 12620

EP +

DI 10.1002/chem.201501529

PD SEP 1 2015

PY 2015

The mild preparation of multifunctional nanocomposite hydrogels is of

   great importance for practical applications. We report that bioinorganic

   nanocomposite hydrogels, with calcium niobate nanosheets as

   cross-linkers, can be prepared by dual-enzyme-triggered polymerization

   and exfoliation of the layered composite. The layered HRP/calcium

   niobate composites (HRP=horseradish peroxidase) are formed by the

   assembly of the calcium niobate nanosheets with HRP. The

   dual-enzyme-triggered polymerization can induce the subsequent

   exfoliation of the layered composite and final gelation through the

   interaction between polymer chains and inorganic nanosheets. The

   self-immobilized HRP-GOx enzymes (GOx=glucose oxidase) within the

   nanocomposite hydrogel retain most of enzymatic activity. Evidently,

   their thermal stability and reusability can be improved. Notably, our

   strategy could be easily extended to other inorganic layered materials

   for the fabrication of other functional nanocomposite hydrogels.

2 Wang, Xia

   Niu, Dechao

   Li, Pei

   Wu, Qing

   Bo, Xiaowan

   Liu, Boji

   Bao, Song

   Su, Teng

   Xu, Huixiong

   Wang, Qigang

Dual-Enzyme-Loaded Multifunctional Hybrid Nanogel System for

   Pathological Responsive Ultrasound Imaging and T-2-Weighted Magnetic

   Resonance Imaging

ACS NANO

VL 9

IS 6

BP 5646

EP 5656

DI 10.1021/nn5068094

PD JUN 2015

PY 2015

A dual-enzyme-loaded multifunctional hybrid nanogel probe

   (SPIO@GCS/acryl/biotin-CAT/SOD-gel, or SGC) has been developed for

   dual-modality pathological responsive ultrasound (US) imaging and

   enhanced T-2-weighted magnetic resonance (MR) imaging. This probe is

   composed of functionalized superparamagnetic iron oxide particles, a

   dual enzyme species (catalase and superoxide dismutase), and a

   polysaccharide cationic polymer glycol chitosan gel. The dual-modality

   US/MR imaging capabilities of the hybrid nanogel for responsive US

   imaging and enhanced T-2-weighted MR imaging have been evaluated both in

   vitro and in vivo. These results show that the hybrid nanogel SGC can

   exhibit efficient dual-enzyme biocatalysis with pathological species for

   responsive US imaging. SEC also demonstrates increased accumulation in

   acidic environments for enhanced T-2-weighted MR imaging. Further

   research on these nanogel systems may lead to the development of more

   efficient US/MR contrast agents.

3 Wang, Xia

   Niu, Dechao

   Wu, Qing

   Bao, Song

   Su, Teng

   Liu, Xiaohang

   Zhang, Shengjian

   Wang, Qigang

Iron oxide/manganese oxide co-loaded hybrid nanogels as pH-responsive

   magnetic resonance contrast agents

SO BIOMATERIALS

VL 53

BP 349

EP 357

DI 10.1016/j.biomaterials.2015.02.101

PD JUN 2015

PY 2015

This work described a proof of concept study of hybrid nanogel-based

   magnetic resonance contrast agents, SPIO@GCS/acryl/biotin@Mn-gel, abb.

   as SGM, for highly efficient, pH-responsive T-1 and T-2 dual-mode

   magnetic resonance imaging (Mm). SGM have been synthesized by assembling

   superparamagnetic iron oxide particles into polysaccharide nanoclusters,

   followed by in-situ reduction of the manganese species on the clusters

   and a final mild polymerization. The dual-mode SGM showed an interesting

   pH-responsiveness in in vitro MRI, with both T-1 and T-2 relaxivities

   turned ON in the acidic environment, along with an increase in the

   r(1) and r(2) relaxivity values by 1.7-fold (from 8.9 to 153 mM(-1) S-1)

   and 4.9-fold (from 45.7 to 226 mM(-1) S-1), due to desirable silencing

   and de-silencing effects. This interesting acidic-responsiveness was

   further verified in vivo with both significantly brightened signal of

   tumor tissue in T-1-weighted MR images and a darkened signal in

   T-2-weighted MR images 50 min post-injection of SGM. This smart hybrid

   nanogel may serve as a promising candidate for further studies of

   dual-mode (T-1 and T-2) contrast agents in MRI, due to its high

   stability, interesting pH-response mechanism and indicative imaging of

   tumors. (C) 2015 Elsevier Ltd. All rights reserved.

4 Wu, Qing

   Wang, Xia

   Liao, Chuanan

   Wei, Qingcong

   Wang, Qigang

Microgel coating of magnetic nanoparticles via bienzyme-mediated

   free-radical polymerization for colorimetric detection of glucose

NANOSCALE

VL 7

IS 40

BP 16578

EP 16582

DI 10.1039/c5nr05716g

PD 2015

PY 2015

This study describes a new strategy for the fabrication of magnetic

   core-shell microgels by free-radical polymerization triggered by the

   cascade reaction of glucose oxidase (GOx) and horseradish peroxidase

   (HRP). The mild polymerization around the interface of the magnetic

   nanoparticles permits the mild coating of the microgel layer with

   excellent characteristics for various applications in biocatalysis and

   medical diagnostics, as well as in clinical fields. The immobilized

   bienzyme within the microgel has a largely retained activity relative to

   the non-immobilized one. The confining effect of the microgel and the

   well designed distance between the two enzymes can benefit the diffusion

   of intermediates to the HRP active site. The final microgels can be

   incontestably employed as sensitive biosensors for colorimetric glucose

   detection.

5 Liu, Xinhua

   Wang, Baofeng

   Jin, Zilu

   Wang, Huanlei

   Wang, Qigang

Elastic ionogels with freeze-aligned pores exhibit enhanced

   electrochemical performances as anisotropic electrolytes of

   all-solid-state supercapacitors

JOURNAL OF MATERIALS CHEMISTRY A

VL 3

IS 30

BP 15408

EP 15412

DI 10.1039/c5ta03184b

PD 2015

PY 2015

Bio-inspired by bone materials, hierarchical porous materials with

   aligned structure have been designed and applied in various fields.

   However, the realization of anisotropic function based on aligned

   structures is still a challenge. Herein, we prepare nanocomposite

   ionogel electrolytes with aligned porous structures via a directional

   freezing of BMIMPF6, PEGMA (PEGDA), and TiO2 at -18 degrees C and

   further TiO2-initiated cryopolymerization under UV irradiation. The

   crystals of PEG derivatives at -18 degrees C provide a directional

   template for the formation of aligned porous structures within the

   ionogel networks. The additional TiO2 nanoparticles, as photoinitiators

   and nanofillers, endow the aligned ionogels with high mechanical

   strength. The aligned ionogel-based supercapacitor exhibits anisotropic

   electrochemical performance and flexibility. The specific capacitance of

   the device with the vertically aligned ionogel is 172 F g(-1) at the

   current density of 1 A g(-1), which is larger than those of the parallel

   aligned and non-aligned devices.

6 Zhang, Ziyang

   Liang, Meiying

   Liu, Xinhua

   Zhao, Fei

   Wang, Baofeng

   Li, Wenjun

   Wang, Qigang

A hybrid gel of hypergravity prepared NiO and polyaniline as Li-ion

   battery anodes

SO RSC ADVANCES

VL 5

IS 107

BP 88419

EP 88424

DI 10.1039/c5ra17929g

PD 2015

PY 2015

The hybrid gel of nickel oxide (NiO) and polyaniline (PANI) was prepared

   and applied as Li-ion battery anodes. Hypergravity NiO nanoparticles was

   obtained by the combination of hydrothermal treatment with a high

   gravity field of 1000g in the 1,2-dichlorobenzene/water system at 120

   degrees C for 0.5 h. The porous PANI gel around the surface of the NiO

   nanoparticles can help the electrons and ions transfer between the NiO

   anode and electrolyte. Electrochemical measurements show that the

   NiO/PANI gel electrode composites exhibit a high reversible capacity of

   455 mA h g(-1) after 100 cycles at a charge-discharge rate of 0.5 C. The

   hybrid gel electrode may provide a favorable approach to optimize the

   electrochemical performance of electrode materials with large volume

   expansion and low electronic conductivity.

7 Zhang, Ziyang

   Tang, Zhou

   Su, Teng

   Li, Wenjun

   Wang, Qigang

Hydrogel-coated enzyme electrodes formed by GOx-mediated polymerization

   for glucose detecting

RSC ADVANCES

VL 5

IS 58

BP 47244

EP 47247

DI 10.1039/c5ra05495h

PD 2015

PY 2015

This communication reports the mild fabrication of a hydrogel-coated

   enzyme electrode for glucose detecting with high sensitivity (35.19 mu A

   mM(-1) cm(-2)) and robust stability.

8 Bao, Song

   Wu, Dongbei

   Su, Teng

   Wu, Qing

   Wang, Qigang

Microgels formed by enzyme-mediated polymerization in reverse micelles

   with tunable activity and high stability

RSC ADVANCES

VL 5

IS 55

BP 44342

EP 44345

DI 10.1039/c5ra02162f

PD 2015

PY 2015

This communication describes the preparation of microgels via

   enzyme-triggered inverse emulsion polymerization, which provides an

   effective method for immobilizing enzymes with tunable catalytic

   performance and high stability.

9 Ye, Yuemei

   Wang, Qigang

A polymer/clay nanocomposite gel via chlorinated paraffin solvent

   initiated photopolymerization with electrorheological performance

RSC ADVANCES

VL 5

IS 10

BP 7752

EP 7754

DI 10.1039/c4ra14275f

PD 2015

PY 2015

This communication reports a mild preparation of a polymer/clay

   nanocomposite gel of chlorinated paraffin with an electrorheological

   response to an external direct-current (DC) voltage due to the alignment

   of the clay within the gel networks.